Exploration
Accueil
Racine
Exploration
Accueil
Racine

Serveur d'exploration sur les relations entre la France et l'Australie

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

Identifieur interne : 002D19 ( Main/Exploration ); précédent : 002D18; suivant : 002D20

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

Auteurs : Daniel I. Swerdlow [Royaume-Uni] ; David Preiss [Royaume-Uni] ; Karoline B. Kuchenbaecker [Royaume-Uni, États-Unis] ; Michael V. Holmes [Royaume-Uni] ; Jorgen E L. Engmann [Royaume-Uni] ; Tina Shah [Royaume-Uni] ; Reecha Sofat [Royaume-Uni] ; Stefan Stender [Danemark] ; Paul C D. Johnson [Royaume-Uni] ; Robert A. Scott [Royaume-Uni] ; Maarten Leusink [Pays-Bas] ; Niek Verweij [Pays-Bas] ; Stephen J. Sharp [Royaume-Uni] ; Yiran Guo [États-Unis] ; Claudia Giambartolomei [Royaume-Uni] ; Christina Chung [Royaume-Uni] ; Anne Peasey [Royaume-Uni] ; Antoinette Amuzu [Royaume-Uni] ; Kawah Li [Royaume-Uni] ; Jutta Palmen [Royaume-Uni] ; Philip Howard [Royaume-Uni] ; Jackie A. Cooper [Royaume-Uni] ; Fotios Drenos [Royaume-Uni] ; Yun R. Li [États-Unis] ; Gordon Lowe [Royaume-Uni] ; John Gallacher [Royaume-Uni] ; Marlene C W. Stewart [Royaume-Uni] ; Ioanna Tzoulaki [Royaume-Uni] ; Sarah G. Buxbaum [États-Unis] ; Daphne L. Van Der A [Pays-Bas] ; Nita G. Forouhi [Royaume-Uni] ; N Charlotte Onland-Moret [Pays-Bas] ; Yvonne T. Van Der Schouw [Pays-Bas] ; Renate B. Schnabel [Allemagne] ; Jaroslav A. Hubacek [République tchèque] ; Ruzena Kubinova [République tchèque] ; Migle Baceviciene [Lituanie] ; Abdonas Tamosiunas [Lituanie] ; Andrzej Pajak [Pologne] ; Romanvan Topor-Madry [Pologne] ; Urszula Stepaniak [Pologne] ; Sofia Malyutina [Russie] ; Damiano Baldassarre [Italie] ; Bengt Sennblad [Suède] ; Elena Tremoli [Italie] ; Ulf De Faire [Suède] ; Fabrizio Veglia [Italie] ; Ian Ford [Royaume-Uni] ; J Wouter Jukema [Pays-Bas] ; Rudi G J. Westendorp [Pays-Bas] ; Gert Jan De Borst [Pays-Bas] ; Pim A. De Jong [Pays-Bas] ; Ale Algra [Pays-Bas] ; Wilko Spiering [Pays-Bas] ; Anke H Maitland-Van Der Zee [Pays-Bas] ; Olaf H. Klungel [Pays-Bas] ; Anthonius De Boer [Pays-Bas] ; Pieter A. Doevendans [Pays-Bas] ; Charles B. Eaton [États-Unis] ; Jennifer G. Robinson [États-Unis] ; David Duggan [États-Unis] ; John Kjekshus [Norvège] ; John R. Downs [États-Unis] ; Antonio M. Gotto [États-Unis] ; Anthony C. Keech [Australie] ; Roberto Marchioli [Italie] ; Gianni Tognoni [Italie] ; Peter S. Sever [Royaume-Uni] ; Neil R. Poulter [Royaume-Uni] ; David D. Waters [États-Unis] ; Terje R. Pedersen [Norvège] ; Pierre Amarenco [France] ; Haruo Nakamura [Japon] ; John J V. Mcmurray [Royaume-Uni] ; James D. Lewsey [Royaume-Uni] ; Daniel I. Chasman [États-Unis] ; Paul M. Ridker [États-Unis] ; Aldo P. Maggioni [Italie] ; Luigi Tavazzi [Italie] ; Kausik K. Ray [Royaume-Uni] ; Sreenivasa Rao Kondapally Seshasai [Royaume-Uni] ; Joann E. Manson [États-Unis] ; Jackie F. Price [Royaume-Uni] ; Peter H. Whincup [Royaume-Uni] ; Richard W. Morris [Royaume-Uni] ; Debbie A. Lawlor [Royaume-Uni] ; George Davey Smith [Royaume-Uni] ; Yoav Ben-Shlomo [Royaume-Uni] ; Pamela J. Schreiner [États-Unis] ; Myriam Fornage [États-Unis] ; David S. Siscovick [États-Unis] ; Mary Cushman [États-Unis] ; Meena Kumari [Royaume-Uni] ; Nick J. Wareham [Royaume-Uni] ; W M Monique Verschuren [Pays-Bas] ; Susan Redline [États-Unis] ; Sanjay R. Patel [États-Unis] ; John C. Whittaker [Royaume-Uni] ; Anders Hamsten [Suède] ; Joseph A. Delaney [États-Unis] ; Caroline Dale [Royaume-Uni] ; Tom R. Gaunt [Royaume-Uni] ; Andrew Wong [Royaume-Uni] ; Diana Kuh [Royaume-Uni] ; Rebecca Hardy [Royaume-Uni] ; Sekar Kathiresan [États-Unis] ; Berta A. Castillo [États-Unis] ; Pim Van Der Harst [Pays-Bas] ; Eric J. Brunner [Royaume-Uni] ; Anne Tybjaerg-Hansen [Danemark] ; Michael G. Marmot [Royaume-Uni] ; Ronald M. Krauss [États-Unis] ; Michael Tsai [États-Unis] ; Josef Coresh [États-Unis] ; Ronald C. Hoogeveen [États-Unis] ; Bruce M. Psaty [États-Unis] ; Leslie A. Lange [États-Unis] ; Hakon Hakonarson [États-Unis] ; Frank Dudbridge [Royaume-Uni] ; Steve E. Humphries [Royaume-Uni] ; Philippa J. Talmud [Royaume-Uni] ; Mika Kivim Ki [Royaume-Uni] ; Nicholas J. Timpson [Royaume-Uni] ; Claudia Langenberg [Royaume-Uni] ; Folkert W. Asselbergs [Royaume-Uni, Pays-Bas] ; Mikhail Voevoda [Russie] ; Martin Bobak [Royaume-Uni] ; Hynek Pikhart [Royaume-Uni] ; James G. Wilson [États-Unis] ; Alex P. Reiner [États-Unis] ; Brendan J. Keating [États-Unis] ; Aroon D. Hingorani [Royaume-Uni] ; Naveed Sattar [Royaume-Uni]

Source :

RBID : PMC:4322187

Descripteurs français

English descriptors

Abstract

SummaryBackground

Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target.

Methods

We used single nucleotide polymorphisms in the HMGCR gene, rs17238484 (for the main analysis) and rs12916 (for a subsidiary analysis) as proxies for HMGCR inhibition by statins. We examined associations of these variants with plasma lipid, glucose, and insulin concentrations; bodyweight; waist circumference; and prevalent and incident type 2 diabetes. Study-specific effect estimates per copy of each LDL-lowering allele were pooled by meta-analysis. These findings were compared with a meta-analysis of new-onset type 2 diabetes and bodyweight change data from randomised trials of statin drugs. The effects of statins in each randomised trial were assessed using meta-analysis.

Findings

Data were available for up to 223 463 individuals from 43 genetic studies. Each additional rs17238484-G allele was associated with a mean 0·06 mmol/L (95% CI 0·05–0·07) lower LDL cholesterol and higher body weight (0·30 kg, 0·18–0·43), waist circumference (0·32 cm, 0·16–0·47), plasma insulin concentration (1·62%, 0·53–2·72), and plasma glucose concentration (0·23%, 0·02–0·44). The rs12916 SNP had similar effects on LDL cholesterol, bodyweight, and waist circumference. The rs17238484-G allele seemed to be associated with higher risk of type 2 diabetes (odds ratio [OR] per allele 1·02, 95% CI 1·00–1·05); the rs12916-T allele association was consistent (1·06, 1·03–1·09). In 129 170 individuals in randomised trials, statins lowered LDL cholesterol by 0·92 mmol/L (95% CI 0·18–1·67) at 1-year of follow-up, increased bodyweight by 0·24 kg (95% CI 0·10–0·38 in all trials; 0·33 kg, 95% CI 0·24–0·42 in placebo or standard care controlled trials and −0·15 kg, 95% CI −0·39 to 0·08 in intensive-dose vs moderate-dose trials) at a mean of 4·2 years (range 1·9–6·7) of follow-up, and increased the odds of new-onset type 2 diabetes (OR 1·12, 95% CI 1·06–1·18 in all trials; 1·11, 95% CI 1·03–1·20 in placebo or standard care controlled trials and 1·12, 95% CI 1·04–1·22 in intensive-dose vs moderate dose trials).

Interpretation

The increased risk of type 2 diabetes noted with statins is at least partially explained by HMGCR inhibition.

Funding

The funding sources are cited at the end of the paper.


Url:
DOI: 10.1016/S0140-6736(14)61183-1
PubMed: 25262344
PubMed Central: 4322187


Affiliations:

Links toward previous steps (curation, corpus...)

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials</title>
<author>
<name sortKey="Swerdlow, Daniel I" sort="Swerdlow, Daniel I" uniqKey="Swerdlow D" first="Daniel I" last="Swerdlow">Daniel I. Swerdlow</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Preiss, David" sort="Preiss, David" uniqKey="Preiss D" first="David" last="Preiss">David Preiss</name>
<affiliation wicri:level="4">
<nlm:aff id="aff8">BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B" last="Kuchenbaecker">Karoline B. Kuchenbaecker</name>
<affiliation wicri:level="4">
<nlm:aff id="aff12">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName>
<settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="aff13">Department of Surgery, Division of Transplantation, and Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Division of Transplantation, and Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Holmes, Michael V" sort="Holmes, Michael V" uniqKey="Holmes M" first="Michael V" last="Holmes">Michael V. Holmes</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Engmann, Jorgen E L" sort="Engmann, Jorgen E L" uniqKey="Engmann J" first="Jorgen E L" last="Engmann">Jorgen E L. Engmann</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Shah, Tina" sort="Shah, Tina" uniqKey="Shah T" first="Tina" last="Shah">Tina Shah</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Sofat, Reecha" sort="Sofat, Reecha" uniqKey="Sofat R" first="Reecha" last="Sofat">Reecha Sofat</name>
<affiliation wicri:level="4">
<nlm:aff id="aff2">UCL Department of Medicine, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Department of Medicine, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Stender, Stefan" sort="Stender, Stefan" uniqKey="Stender S" first="Stefan" last="Stender">Stefan Stender</name>
<affiliation wicri:level="3">
<nlm:aff id="aff14">Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Johnson, Paul C D" sort="Johnson, Paul C D" uniqKey="Johnson P" first="Paul C D" last="Johnson">Paul C D. Johnson</name>
<affiliation wicri:level="4">
<nlm:aff id="aff9">Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A" last="Scott">Robert A. Scott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Leusink, Maarten" sort="Leusink, Maarten" uniqKey="Leusink M" first="Maarten" last="Leusink">Maarten Leusink</name>
<affiliation wicri:level="4">
<nlm:aff id="aff16">Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
<settlement type="city">Utrecht</settlement>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author>
<name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name>
<affiliation wicri:level="4">
<nlm:aff id="aff17">University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
<settlement type="city">Groningue (ville)</settlement>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author>
<name sortKey="Sharp, Stephen J" sort="Sharp, Stephen J" uniqKey="Sharp S" first="Stephen J" last="Sharp">Stephen J. Sharp</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Guo, Yiran" sort="Guo, Yiran" uniqKey="Guo Y" first="Yiran" last="Guo">Yiran Guo</name>
<affiliation wicri:level="2">
<nlm:aff id="aff18">Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Giambartolomei, Claudia" sort="Giambartolomei, Claudia" uniqKey="Giambartolomei C" first="Claudia" last="Giambartolomei">Claudia Giambartolomei</name>
<affiliation wicri:level="4">
<nlm:aff id="aff4">UCL Genetics Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Genetics Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Chung, Christina" sort="Chung, Christina" uniqKey="Chung C" first="Christina" last="Chung">Christina Chung</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Peasey, Anne" sort="Peasey, Anne" uniqKey="Peasey A" first="Anne" last="Peasey">Anne Peasey</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Amuzu, Antoinette" sort="Amuzu, Antoinette" uniqKey="Amuzu A" first="Antoinette" last="Amuzu">Antoinette Amuzu</name>
<affiliation wicri:level="3">
<nlm:aff id="aff20">London School of Hygiene & Tropical Medicine, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene & Tropical Medicine, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Li, Kawah" sort="Li, Kawah" uniqKey="Li K" first="Kawah" last="Li">Kawah Li</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Palmen, Jutta" sort="Palmen, Jutta" uniqKey="Palmen J" first="Jutta" last="Palmen">Jutta Palmen</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Howard, Philip" sort="Howard, Philip" uniqKey="Howard P" first="Philip" last="Howard">Philip Howard</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Cooper, Jackie A" sort="Cooper, Jackie A" uniqKey="Cooper J" first="Jackie A" last="Cooper">Jackie A. Cooper</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Drenos, Fotios" sort="Drenos, Fotios" uniqKey="Drenos F" first="Fotios" last="Drenos">Fotios Drenos</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Li, Yun R" sort="Li, Yun R" uniqKey="Li Y" first="Yun R" last="Li">Yun R. Li</name>
<affiliation wicri:level="2">
<nlm:aff id="aff18">Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lowe, Gordon" sort="Lowe, Gordon" uniqKey="Lowe G" first="Gordon" last="Lowe">Gordon Lowe</name>
<affiliation wicri:level="4">
<nlm:aff id="aff10">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">Department of Primary Care and Public Health, Cardiff University Medical School, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Primary Care and Public Health, Cardiff University Medical School, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Stewart, Marlene C W" sort="Stewart, Marlene C W" uniqKey="Stewart M" first="Marlene C W" last="Stewart">Marlene C W. Stewart</name>
<affiliation wicri:level="4">
<nlm:aff id="aff22">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name>
<affiliation wicri:level="3">
<nlm:aff id="aff23">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Buxbaum, Sarah G" sort="Buxbaum, Sarah G" uniqKey="Buxbaum S" first="Sarah G" last="Buxbaum">Sarah G. Buxbaum</name>
<affiliation wicri:level="2">
<nlm:aff id="aff25">Jackson State University, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Jackson State University, Jackson, MS</wicri:regionArea>
<placeName>
<region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Der A, Daphne L" sort="Van Der A, Daphne L" uniqKey="Van Der A D" first="Daphne L" last="Van Der A">Daphne L. Van Der A</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">National Institute for Public Health and the Environment, Bilthoven, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name>
<affiliation wicri:level="3">
<nlm:aff id="aff27">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name>
<affiliation wicri:level="3">
<nlm:aff id="aff27">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schnabel, Renate B" sort="Schnabel, Renate B" uniqKey="Schnabel R" first="Renate B" last="Schnabel">Renate B. Schnabel</name>
<affiliation wicri:level="3">
<nlm:aff id="aff33">University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg</wicri:regionArea>
<placeName>
<settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hubacek, Jaroslav A" sort="Hubacek, Jaroslav A" uniqKey="Hubacek J" first="Jaroslav A" last="Hubacek">Jaroslav A. Hubacek</name>
<affiliation wicri:level="3">
<nlm:aff id="aff34">Centre for Experimental Medicine, Institute of Clinical and Experimental Medicine, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Centre for Experimental Medicine, Institute of Clinical and Experimental Medicine, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kubinova, Ruzena" sort="Kubinova, Ruzena" uniqKey="Kubinova R" first="Ruzena" last="Kubinova">Ruzena Kubinova</name>
<affiliation wicri:level="3">
<nlm:aff id="aff35">National Institute of Public Health, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>National Institute of Public Health, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Baceviciene, Migle" sort="Baceviciene, Migle" uniqKey="Baceviciene M" first="Migle" last="Baceviciene">Migle Baceviciene</name>
<affiliation wicri:level="1">
<nlm:aff id="aff37">Lithuanian University of Health Sciences, Kaunas, Lithuania</nlm:aff>
<country xml:lang="fr">Lituanie</country>
<wicri:regionArea>Lithuanian University of Health Sciences, Kaunas</wicri:regionArea>
<wicri:noRegion>Kaunas</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Tamosiunas, Abdonas" sort="Tamosiunas, Abdonas" uniqKey="Tamosiunas A" first="Abdonas" last="Tamosiunas">Abdonas Tamosiunas</name>
<affiliation wicri:level="1">
<nlm:aff id="aff36">Institute of Cardiology, Kaunas, Lithuania</nlm:aff>
<country xml:lang="fr">Lituanie</country>
<wicri:regionArea>Institute of Cardiology, Kaunas</wicri:regionArea>
<wicri:noRegion>Kaunas</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pajak, Andrzej" sort="Pajak, Andrzej" uniqKey="Pajak A" first="Andrzej" last="Pajak">Andrzej Pajak</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Topor Madry, Romanvan" sort="Topor Madry, Romanvan" uniqKey="Topor Madry R" first="Romanvan" last="Topor-Madry">Romanvan Topor-Madry</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Stepaniak, Urszula" sort="Stepaniak, Urszula" uniqKey="Stepaniak U" first="Urszula" last="Stepaniak">Urszula Stepaniak</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Malyutina, Sofia" sort="Malyutina, Sofia" uniqKey="Malyutina S" first="Sofia" last="Malyutina">Sofia Malyutina</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk</wicri:regionArea>
<wicri:noRegion>Novosibirsk</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Baldassarre, Damiano" sort="Baldassarre, Damiano" uniqKey="Baldassarre D" first="Damiano" last="Baldassarre">Damiano Baldassarre</name>
<affiliation wicri:level="3">
<nlm:aff id="aff41">Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff46">Centro Cardiologico Monzino IRCCS Milan, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Centro Cardiologico Monzino IRCCS Milan, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
<affiliation wicri:level="3">
<nlm:aff id="aff42">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff43">Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Science for Life Laboratory, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name>
<affiliation wicri:level="3">
<nlm:aff id="aff41">Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff46">Centro Cardiologico Monzino IRCCS Milan, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Centro Cardiologico Monzino IRCCS Milan, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name>
<affiliation wicri:level="3">
<nlm:aff id="aff44">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Veglia, Fabrizio" sort="Veglia, Fabrizio" uniqKey="Veglia F" first="Fabrizio" last="Veglia">Fabrizio Veglia</name>
<affiliation wicri:level="3">
<nlm:aff id="aff45">Biostatistics Unit, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Biostatistics Unit, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation wicri:level="4">
<nlm:aff id="aff9">Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name>
<affiliation wicri:level="3">
<nlm:aff id="aff47">Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Westendorp, Rudi G J" sort="Westendorp, Rudi G J" uniqKey="Westendorp R" first="Rudi G J" last="Westendorp">Rudi G J. Westendorp</name>
<affiliation wicri:level="3">
<nlm:aff id="aff48">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="De Borst, Gert Jan" sort="De Borst, Gert Jan" uniqKey="De Borst G" first="Gert Jan" last="De Borst">Gert Jan De Borst</name>
<affiliation wicri:level="3">
<nlm:aff id="aff28">Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Surgery, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="De Jong, Pim A" sort="De Jong, Pim A" uniqKey="De Jong P" first="Pim A" last="De Jong">Pim A. De Jong</name>
<affiliation wicri:level="3">
<nlm:aff id="aff29">Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name>
<affiliation wicri:level="3">
<nlm:aff id="aff27">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff30">Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Spiering, Wilko" sort="Spiering, Wilko" uniqKey="Spiering W" first="Wilko" last="Spiering">Wilko Spiering</name>
<affiliation wicri:level="3">
<nlm:aff id="aff31">Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Der Zee, Anke H Maitland Van" sort="Der Zee, Anke H Maitland Van" uniqKey="Der Zee A" first="Anke H Maitland-Van" last="Der Zee">Anke H Maitland-Van Der Zee</name>
<affiliation wicri:level="4">
<nlm:aff id="aff16">Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
<settlement type="city">Utrecht</settlement>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author>
<name sortKey="Klungel, Olaf H" sort="Klungel, Olaf H" uniqKey="Klungel O" first="Olaf H" last="Klungel">Olaf H. Klungel</name>
<affiliation wicri:level="4">
<nlm:aff id="aff16">Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
<settlement type="city">Utrecht</settlement>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author>
<name sortKey="De Boer, Anthonius" sort="De Boer, Anthonius" uniqKey="De Boer A" first="Anthonius" last="De Boer">Anthonius De Boer</name>
<affiliation wicri:level="4">
<nlm:aff id="aff16">Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
<settlement type="city">Utrecht</settlement>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author>
<name sortKey="Doevendans, Pieter A" sort="Doevendans, Pieter A" uniqKey="Doevendans P" first="Pieter A" last="Doevendans">Pieter A. Doevendans</name>
<affiliation wicri:level="3">
<nlm:aff id="aff32">Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Eaton, Charles B" sort="Eaton, Charles B" uniqKey="Eaton C" first="Charles B" last="Eaton">Charles B. Eaton</name>
<affiliation wicri:level="2">
<nlm:aff id="aff49">Memorial Hospital of Rhode Island, RI, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memorial Hospital of Rhode Island, RI</wicri:regionArea>
<placeName>
<region type="state">Rhode Island</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Robinson, Jennifer G" sort="Robinson, Jennifer G" uniqKey="Robinson J" first="Jennifer G" last="Robinson">Jennifer G. Robinson</name>
<affiliation wicri:level="4">
<nlm:aff id="aff50">University of Iowa, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa, IA</wicri:regionArea>
<placeName>
<region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author>
<name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name>
<affiliation wicri:level="2">
<nlm:aff id="aff51">Translational Genomics Research Institute, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea>
<placeName>
<region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kjekshus, John" sort="Kjekshus, John" uniqKey="Kjekshus J" first="John" last="Kjekshus">John Kjekshus</name>
<affiliation wicri:level="3">
<nlm:aff id="aff52">Department of Cardiology, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Cardiology, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo</wicri:regionArea>
<placeName>
<settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R" last="Downs">John R. Downs</name>
<affiliation wicri:level="2">
<nlm:aff id="aff54">Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Texas Health Science Centre, San Antonio, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="aff55">VERDICT, South Texas Veterans Health Care System, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>VERDICT, South Texas Veterans Health Care System, San Antonio, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gotto, Antonio M" sort="Gotto, Antonio M" uniqKey="Gotto A" first="Antonio M" last="Gotto">Antonio M. Gotto</name>
<affiliation wicri:level="2">
<nlm:aff id="aff56">Weill Cornell Medical College, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Weill Cornell Medical College, New York, NY</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Keech, Anthony C" sort="Keech, Anthony C" uniqKey="Keech A" first="Anthony C" last="Keech">Anthony C. Keech</name>
<affiliation wicri:level="4">
<nlm:aff id="aff57">NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Marchioli, Roberto" sort="Marchioli, Roberto" uniqKey="Marchioli R" first="Roberto" last="Marchioli">Roberto Marchioli</name>
<affiliation wicri:level="3">
<nlm:aff id="aff58">Hematology and Oncology Therapeutic Delivery Unit, Quintiles, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Hematology and Oncology Therapeutic Delivery Unit, Quintiles, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tognoni, Gianni" sort="Tognoni, Gianni" uniqKey="Tognoni G" first="Gianni" last="Tognoni">Gianni Tognoni</name>
<affiliation wicri:level="1">
<nlm:aff id="aff59">Department of Clinical Pharmacology and Epidemiology, Consorzio Mario NegriSud, Santa Maria Imbaro, Chieti, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Clinical Pharmacology and Epidemiology, Consorzio Mario NegriSud, Santa Maria Imbaro, Chieti</wicri:regionArea>
<wicri:noRegion>Chieti</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Sever, Peter S" sort="Sever, Peter S" uniqKey="Sever P" first="Peter S" last="Sever">Peter S. Sever</name>
<affiliation wicri:level="3">
<nlm:aff id="aff24">International Centre for Circulatory Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Centre for Circulatory Health, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Poulter, Neil R" sort="Poulter, Neil R" uniqKey="Poulter N" first="Neil R" last="Poulter">Neil R. Poulter</name>
<affiliation wicri:level="3">
<nlm:aff id="aff24">International Centre for Circulatory Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Centre for Circulatory Health, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D" last="Waters">David D. Waters</name>
<affiliation wicri:level="2">
<nlm:aff id="aff60">Department of Medicine, University of California, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of California, San Francisco, CA</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R" last="Pedersen">Terje R. Pedersen</name>
<affiliation wicri:level="3">
<nlm:aff id="aff53">Centre for Preventative Medicine, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Centre for Preventative Medicine, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo</wicri:regionArea>
<placeName>
<settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name>
<affiliation wicri:level="3">
<nlm:aff id="aff61">Denis Diderot University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Denis Diderot University, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nakamura, Haruo" sort="Nakamura, Haruo" uniqKey="Nakamura H" first="Haruo" last="Nakamura">Haruo Nakamura</name>
<affiliation wicri:level="3">
<nlm:aff id="aff62">Mitsukoshi Health and Welfare Foundation, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Mitsukoshi Health and Welfare Foundation, Tokyo</wicri:regionArea>
<placeName>
<settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mcmurray, John J V" sort="Mcmurray, John J V" uniqKey="Mcmurray J" first="John J V" last="Mcmurray">John J V. Mcmurray</name>
<affiliation wicri:level="4">
<nlm:aff id="aff8">BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lewsey, James D" sort="Lewsey, James D" uniqKey="Lewsey J" first="James D" last="Lewsey">James D. Lewsey</name>
<affiliation wicri:level="4">
<nlm:aff id="aff11">Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Health and Wellbeing, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name>
<affiliation wicri:level="2">
<nlm:aff id="aff63">Division of Preventive Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="2">
<nlm:aff id="aff63">Division of Preventive Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P" last="Maggioni">Aldo P. Maggioni</name>
<affiliation wicri:level="1">
<nlm:aff id="aff66">ANMCO Research Center, Florence, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>ANMCO Research Center, Florence</wicri:regionArea>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Tavazzi, Luigi" sort="Tavazzi, Luigi" uniqKey="Tavazzi L" first="Luigi" last="Tavazzi">Luigi Tavazzi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff67">Maria Cecilia Hospital, GVM Care and Research, E.S. Health Science Foundation, Cotignola (RA), Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Maria Cecilia Hospital, GVM Care and Research, E.S. Health Science Foundation, Cotignola (RA)</wicri:regionArea>
<wicri:noRegion>Cotignola (RA)</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ray, Kausik K" sort="Ray, Kausik K" uniqKey="Ray K" first="Kausik K" last="Ray">Kausik K. Ray</name>
<affiliation wicri:level="3">
<nlm:aff id="aff68">Cardiac and Cell Sciences Research Institute, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiac and Cell Sciences Research Institute, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Seshasai, Sreenivasa Rao Kondapally" sort="Seshasai, Sreenivasa Rao Kondapally" uniqKey="Seshasai S" first="Sreenivasa Rao Kondapally" last="Seshasai">Sreenivasa Rao Kondapally Seshasai</name>
<affiliation wicri:level="3">
<nlm:aff id="aff68">Cardiac and Cell Sciences Research Institute, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiac and Cell Sciences Research Institute, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name>
<affiliation wicri:level="2">
<nlm:aff id="aff63">Division of Preventive Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name>
<affiliation wicri:level="4">
<nlm:aff id="aff22">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Whincup, Peter H" sort="Whincup, Peter H" uniqKey="Whincup P" first="Peter H" last="Whincup">Peter H. Whincup</name>
<affiliation wicri:level="4">
<nlm:aff id="aff69">St George's University of London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>St George's University of London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Morris, Richard W" sort="Morris, Richard W" uniqKey="Morris R" first="Richard W" last="Morris">Richard W. Morris</name>
<affiliation wicri:level="4">
<nlm:aff id="aff5">UCL Department of Primary Care and Population Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Department of Primary Care and Population Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Integrative Epidemiology Unit, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff71">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Integrative Epidemiology Unit, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff71">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name>
<affiliation wicri:level="1">
<nlm:aff id="aff71">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schreiner, Pamela J" sort="Schreiner, Pamela J" uniqKey="Schreiner P" first="Pamela J" last="Schreiner">Pamela J. Schreiner</name>
<affiliation wicri:level="2">
<nlm:aff id="aff72">School of Public Health, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Public Health, Minneapolis, MN</wicri:regionArea>
<placeName>
<region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2">
<nlm:aff id="aff74">Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name>
<affiliation wicri:level="4">
<nlm:aff id="aff75">Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
<placeName>
<region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author>
<name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name>
<affiliation wicri:level="2">
<nlm:aff id="aff77">Departments of Medicine and Pathology, University of Vermont, Colchester, VT, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Medicine and Pathology, University of Vermont, Colchester, VT</wicri:regionArea>
<placeName>
<region type="state">Vermont</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J" last="Wareham">Nick J. Wareham</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Verschuren, W M Monique" sort="Verschuren, W M Monique" uniqKey="Verschuren W" first="W M Monique" last="Verschuren">W M Monique Verschuren</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">National Institute for Public Health and the Environment, Bilthoven, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name>
<affiliation wicri:level="2">
<nlm:aff id="aff65">Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women's Hospital, Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Patel, Sanjay R" sort="Patel, Sanjay R" uniqKey="Patel S" first="Sanjay R" last="Patel">Sanjay R. Patel</name>
<affiliation wicri:level="2">
<nlm:aff id="aff64">Division of Sleep Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Sleep Medicine, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Whittaker, John C" sort="Whittaker, John C" uniqKey="Whittaker J" first="John C" last="Whittaker">John C. Whittaker</name>
<affiliation wicri:level="1">
<nlm:aff id="aff78">GlaxoSmithKline, Stevenage, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>GlaxoSmithKline, Stevenage</wicri:regionArea>
<wicri:noRegion>Stevenage</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<affiliation wicri:level="3">
<nlm:aff id="aff42">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Delaney, Joseph A" sort="Delaney, Joseph A" uniqKey="Delaney J" first="Joseph A" last="Delaney">Joseph A. Delaney</name>
<affiliation wicri:level="4">
<nlm:aff id="aff76">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
<placeName>
<region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author>
<name sortKey="Dale, Caroline" sort="Dale, Caroline" uniqKey="Dale C" first="Caroline" last="Dale">Caroline Dale</name>
<affiliation wicri:level="3">
<nlm:aff id="aff19">Department of Non-Communicable Disease Epidemiology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gaunt, Tom R" sort="Gaunt, Tom R" uniqKey="Gaunt T" first="Tom R" last="Gaunt">Tom R. Gaunt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Integrative Epidemiology Unit, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name>
<affiliation wicri:level="4">
<nlm:aff id="aff7">MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name>
<affiliation wicri:level="4">
<nlm:aff id="aff7">MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Hardy, Rebecca" sort="Hardy, Rebecca" uniqKey="Hardy R" first="Rebecca" last="Hardy">Rebecca Hardy</name>
<affiliation wicri:level="4">
<nlm:aff id="aff7">MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<affiliation wicri:level="2">
<nlm:aff id="aff79">Cardiology Division, Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiology Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="aff80">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Castillo, Berta A" sort="Castillo, Berta A" uniqKey="Castillo B" first="Berta A" last="Castillo">Berta A. Castillo</name>
<affiliation wicri:level="2">
<nlm:aff id="aff18">Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name>
<affiliation wicri:level="4">
<nlm:aff id="aff17">University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
<settlement type="city">Groningue (ville)</settlement>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author>
<name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J" last="Brunner">Eric J. Brunner</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Tybjaerg Hansen, Anne" sort="Tybjaerg Hansen, Anne" uniqKey="Tybjaerg Hansen A" first="Anne" last="Tybjaerg-Hansen">Anne Tybjaerg-Hansen</name>
<affiliation wicri:level="3">
<nlm:aff id="aff14">Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Marmot, Michael G" sort="Marmot, Michael G" uniqKey="Marmot M" first="Michael G" last="Marmot">Michael G. Marmot</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Krauss, Ronald M" sort="Krauss, Ronald M" uniqKey="Krauss R" first="Ronald M" last="Krauss">Ronald M. Krauss</name>
<affiliation wicri:level="2">
<nlm:aff id="aff81">Children's Hospital Oakland Research Institute, Oakland, CA USA</nlm:aff>
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Children's Hospital Oakland Research Institute, Oakland</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Tsai, Michael" sort="Tsai, Michael" uniqKey="Tsai M" first="Michael" last="Tsai">Michael Tsai</name>
<affiliation wicri:level="2">
<nlm:aff id="aff73">University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName>
<region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name>
<affiliation wicri:level="2">
<nlm:aff id="aff82">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD</wicri:regionArea>
<placeName>
<region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hoogeveen, Ronald C" sort="Hoogeveen, Ronald C" uniqKey="Hoogeveen R" first="Ronald C" last="Hoogeveen">Ronald C. Hoogeveen</name>
<affiliation wicri:level="2">
<nlm:aff id="aff83">Baylor College of Medicine, Department of Medicine, Division of Atherosclerosis and Vascular Medicine, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Baylor College of Medicine, Department of Medicine, Division of Atherosclerosis and Vascular Medicine, Houston, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name>
<affiliation wicri:level="4">
<nlm:aff id="aff75">Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
<placeName>
<region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author>
<name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name>
<affiliation wicri:level="2">
<nlm:aff id="aff84">Department of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name>
<affiliation wicri:level="2">
<nlm:aff id="aff18">Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name>
<affiliation wicri:level="3">
<nlm:aff id="aff20">London School of Hygiene & Tropical Medicine, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene & Tropical Medicine, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Talmud, Philippa J" sort="Talmud, Philippa J" uniqKey="Talmud P" first="Philippa J" last="Talmud">Philippa J. Talmud</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Kivim Ki, Mika" sort="Kivim Ki, Mika" uniqKey="Kivim Ki M" first="Mika" last="Kivim Ki">Mika Kivim Ki</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Integrative Epidemiology Unit, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff71">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff32">Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff85">Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Voevoda, Mikhail" sort="Voevoda, Mikhail" uniqKey="Voevoda M" first="Mikhail" last="Voevoda">Mikhail Voevoda</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk</wicri:regionArea>
<wicri:noRegion>Novosibirsk</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff40">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk</wicri:regionArea>
<wicri:noRegion>Novosibirsk</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Bobak, Martin" sort="Bobak, Martin" uniqKey="Bobak M" first="Martin" last="Bobak">Martin Bobak</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Pikhart, Hynek" sort="Pikhart, Hynek" uniqKey="Pikhart H" first="Hynek" last="Pikhart">Hynek Pikhart</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Wilson, James G" sort="Wilson, James G" uniqKey="Wilson J" first="James G" last="Wilson">James G. Wilson</name>
<affiliation wicri:level="2">
<nlm:aff id="aff86">Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName>
<region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name>
<affiliation wicri:level="2">
<nlm:aff id="aff87">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name>
<affiliation wicri:level="2">
<nlm:aff id="aff18">Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation wicri:level="4">
<nlm:aff id="aff8">BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">25262344</idno>
<idno type="pmc">4322187</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322187</idno>
<idno type="RBID">PMC:4322187</idno>
<idno type="doi">10.1016/S0140-6736(14)61183-1</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">002738</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002738</idno>
<idno type="wicri:Area/Pmc/Curation">002588</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002588</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000F54</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000F54</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003198</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003198</idno>
<idno type="wicri:Area/PubMed/Curation">003088</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003088</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003088</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003088</idno>
<idno type="wicri:Area/Ncbi/Merge">001E48</idno>
<idno type="wicri:Area/Ncbi/Curation">001E48</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001E48</idno>
<idno type="wicri:doubleKey">0140-6736:2015:Swerdlow D:hmg:coenzyme:a</idno>
<idno type="wicri:Area/Main/Merge">002D19</idno>
<idno type="wicri:Area/Main/Curation">002D19</idno>
<idno type="wicri:Area/Main/Exploration">002D19</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials</title>
<author>
<name sortKey="Swerdlow, Daniel I" sort="Swerdlow, Daniel I" uniqKey="Swerdlow D" first="Daniel I" last="Swerdlow">Daniel I. Swerdlow</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Preiss, David" sort="Preiss, David" uniqKey="Preiss D" first="David" last="Preiss">David Preiss</name>
<affiliation wicri:level="4">
<nlm:aff id="aff8">BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B" last="Kuchenbaecker">Karoline B. Kuchenbaecker</name>
<affiliation wicri:level="4">
<nlm:aff id="aff12">Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName>
<settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="aff13">Department of Surgery, Division of Transplantation, and Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Division of Transplantation, and Clinical Epidemiology Unit, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Holmes, Michael V" sort="Holmes, Michael V" uniqKey="Holmes M" first="Michael V" last="Holmes">Michael V. Holmes</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Engmann, Jorgen E L" sort="Engmann, Jorgen E L" uniqKey="Engmann J" first="Jorgen E L" last="Engmann">Jorgen E L. Engmann</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Shah, Tina" sort="Shah, Tina" uniqKey="Shah T" first="Tina" last="Shah">Tina Shah</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Sofat, Reecha" sort="Sofat, Reecha" uniqKey="Sofat R" first="Reecha" last="Sofat">Reecha Sofat</name>
<affiliation wicri:level="4">
<nlm:aff id="aff2">UCL Department of Medicine, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Department of Medicine, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Stender, Stefan" sort="Stender, Stefan" uniqKey="Stender S" first="Stefan" last="Stender">Stefan Stender</name>
<affiliation wicri:level="3">
<nlm:aff id="aff14">Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Johnson, Paul C D" sort="Johnson, Paul C D" uniqKey="Johnson P" first="Paul C D" last="Johnson">Paul C D. Johnson</name>
<affiliation wicri:level="4">
<nlm:aff id="aff9">Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A" last="Scott">Robert A. Scott</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Leusink, Maarten" sort="Leusink, Maarten" uniqKey="Leusink M" first="Maarten" last="Leusink">Maarten Leusink</name>
<affiliation wicri:level="4">
<nlm:aff id="aff16">Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
<settlement type="city">Utrecht</settlement>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author>
<name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name>
<affiliation wicri:level="4">
<nlm:aff id="aff17">University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
<settlement type="city">Groningue (ville)</settlement>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author>
<name sortKey="Sharp, Stephen J" sort="Sharp, Stephen J" uniqKey="Sharp S" first="Stephen J" last="Sharp">Stephen J. Sharp</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Guo, Yiran" sort="Guo, Yiran" uniqKey="Guo Y" first="Yiran" last="Guo">Yiran Guo</name>
<affiliation wicri:level="2">
<nlm:aff id="aff18">Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Giambartolomei, Claudia" sort="Giambartolomei, Claudia" uniqKey="Giambartolomei C" first="Claudia" last="Giambartolomei">Claudia Giambartolomei</name>
<affiliation wicri:level="4">
<nlm:aff id="aff4">UCL Genetics Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Genetics Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Chung, Christina" sort="Chung, Christina" uniqKey="Chung C" first="Christina" last="Chung">Christina Chung</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Peasey, Anne" sort="Peasey, Anne" uniqKey="Peasey A" first="Anne" last="Peasey">Anne Peasey</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Amuzu, Antoinette" sort="Amuzu, Antoinette" uniqKey="Amuzu A" first="Antoinette" last="Amuzu">Antoinette Amuzu</name>
<affiliation wicri:level="3">
<nlm:aff id="aff20">London School of Hygiene & Tropical Medicine, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene & Tropical Medicine, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Li, Kawah" sort="Li, Kawah" uniqKey="Li K" first="Kawah" last="Li">Kawah Li</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Palmen, Jutta" sort="Palmen, Jutta" uniqKey="Palmen J" first="Jutta" last="Palmen">Jutta Palmen</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Howard, Philip" sort="Howard, Philip" uniqKey="Howard P" first="Philip" last="Howard">Philip Howard</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Cooper, Jackie A" sort="Cooper, Jackie A" uniqKey="Cooper J" first="Jackie A" last="Cooper">Jackie A. Cooper</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Drenos, Fotios" sort="Drenos, Fotios" uniqKey="Drenos F" first="Fotios" last="Drenos">Fotios Drenos</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Li, Yun R" sort="Li, Yun R" uniqKey="Li Y" first="Yun R" last="Li">Yun R. Li</name>
<affiliation wicri:level="2">
<nlm:aff id="aff18">Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lowe, Gordon" sort="Lowe, Gordon" uniqKey="Lowe G" first="Gordon" last="Lowe">Gordon Lowe</name>
<affiliation wicri:level="4">
<nlm:aff id="aff10">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name>
<affiliation wicri:level="1">
<nlm:aff id="aff21">Department of Primary Care and Public Health, Cardiff University Medical School, Cardiff University, Cardiff, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Primary Care and Public Health, Cardiff University Medical School, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Stewart, Marlene C W" sort="Stewart, Marlene C W" uniqKey="Stewart M" first="Marlene C W" last="Stewart">Marlene C W. Stewart</name>
<affiliation wicri:level="4">
<nlm:aff id="aff22">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name>
<affiliation wicri:level="3">
<nlm:aff id="aff23">Department of Epidemiology and Biostatistics, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Buxbaum, Sarah G" sort="Buxbaum, Sarah G" uniqKey="Buxbaum S" first="Sarah G" last="Buxbaum">Sarah G. Buxbaum</name>
<affiliation wicri:level="2">
<nlm:aff id="aff25">Jackson State University, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Jackson State University, Jackson, MS</wicri:regionArea>
<placeName>
<region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Der A, Daphne L" sort="Van Der A, Daphne L" uniqKey="Van Der A D" first="Daphne L" last="Van Der A">Daphne L. Van Der A</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">National Institute for Public Health and the Environment, Bilthoven, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name>
<affiliation wicri:level="3">
<nlm:aff id="aff27">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name>
<affiliation wicri:level="3">
<nlm:aff id="aff27">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schnabel, Renate B" sort="Schnabel, Renate B" uniqKey="Schnabel R" first="Renate B" last="Schnabel">Renate B. Schnabel</name>
<affiliation wicri:level="3">
<nlm:aff id="aff33">University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg</wicri:regionArea>
<placeName>
<settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hubacek, Jaroslav A" sort="Hubacek, Jaroslav A" uniqKey="Hubacek J" first="Jaroslav A" last="Hubacek">Jaroslav A. Hubacek</name>
<affiliation wicri:level="3">
<nlm:aff id="aff34">Centre for Experimental Medicine, Institute of Clinical and Experimental Medicine, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>Centre for Experimental Medicine, Institute of Clinical and Experimental Medicine, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kubinova, Ruzena" sort="Kubinova, Ruzena" uniqKey="Kubinova R" first="Ruzena" last="Kubinova">Ruzena Kubinova</name>
<affiliation wicri:level="3">
<nlm:aff id="aff35">National Institute of Public Health, Prague, Czech Republic</nlm:aff>
<country xml:lang="fr">République tchèque</country>
<wicri:regionArea>National Institute of Public Health, Prague</wicri:regionArea>
<placeName>
<settlement type="city">Prague</settlement>
<region type="région" nuts="2">Bohême centrale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Baceviciene, Migle" sort="Baceviciene, Migle" uniqKey="Baceviciene M" first="Migle" last="Baceviciene">Migle Baceviciene</name>
<affiliation wicri:level="1">
<nlm:aff id="aff37">Lithuanian University of Health Sciences, Kaunas, Lithuania</nlm:aff>
<country xml:lang="fr">Lituanie</country>
<wicri:regionArea>Lithuanian University of Health Sciences, Kaunas</wicri:regionArea>
<wicri:noRegion>Kaunas</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Tamosiunas, Abdonas" sort="Tamosiunas, Abdonas" uniqKey="Tamosiunas A" first="Abdonas" last="Tamosiunas">Abdonas Tamosiunas</name>
<affiliation wicri:level="1">
<nlm:aff id="aff36">Institute of Cardiology, Kaunas, Lithuania</nlm:aff>
<country xml:lang="fr">Lituanie</country>
<wicri:regionArea>Institute of Cardiology, Kaunas</wicri:regionArea>
<wicri:noRegion>Kaunas</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pajak, Andrzej" sort="Pajak, Andrzej" uniqKey="Pajak A" first="Andrzej" last="Pajak">Andrzej Pajak</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Topor Madry, Romanvan" sort="Topor Madry, Romanvan" uniqKey="Topor Madry R" first="Romanvan" last="Topor-Madry">Romanvan Topor-Madry</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Stepaniak, Urszula" sort="Stepaniak, Urszula" uniqKey="Stepaniak U" first="Urszula" last="Stepaniak">Urszula Stepaniak</name>
<affiliation wicri:level="1">
<nlm:aff id="aff38">Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow</wicri:regionArea>
<wicri:noRegion>Krakow</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Malyutina, Sofia" sort="Malyutina, Sofia" uniqKey="Malyutina S" first="Sofia" last="Malyutina">Sofia Malyutina</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk</wicri:regionArea>
<wicri:noRegion>Novosibirsk</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Baldassarre, Damiano" sort="Baldassarre, Damiano" uniqKey="Baldassarre D" first="Damiano" last="Baldassarre">Damiano Baldassarre</name>
<affiliation wicri:level="3">
<nlm:aff id="aff41">Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff46">Centro Cardiologico Monzino IRCCS Milan, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Centro Cardiologico Monzino IRCCS Milan, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
<affiliation wicri:level="3">
<nlm:aff id="aff42">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff43">Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Science for Life Laboratory, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name>
<affiliation wicri:level="3">
<nlm:aff id="aff41">Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff46">Centro Cardiologico Monzino IRCCS Milan, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Centro Cardiologico Monzino IRCCS Milan, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name>
<affiliation wicri:level="3">
<nlm:aff id="aff44">Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Veglia, Fabrizio" sort="Veglia, Fabrizio" uniqKey="Veglia F" first="Fabrizio" last="Veglia">Fabrizio Veglia</name>
<affiliation wicri:level="3">
<nlm:aff id="aff45">Biostatistics Unit, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Biostatistics Unit, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation wicri:level="4">
<nlm:aff id="aff9">Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Robertson Centre for Biostatistics, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name>
<affiliation wicri:level="3">
<nlm:aff id="aff47">Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Westendorp, Rudi G J" sort="Westendorp, Rudi G J" uniqKey="Westendorp R" first="Rudi G J" last="Westendorp">Rudi G J. Westendorp</name>
<affiliation wicri:level="3">
<nlm:aff id="aff48">Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="De Borst, Gert Jan" sort="De Borst, Gert Jan" uniqKey="De Borst G" first="Gert Jan" last="De Borst">Gert Jan De Borst</name>
<affiliation wicri:level="3">
<nlm:aff id="aff28">Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Surgery, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="De Jong, Pim A" sort="De Jong, Pim A" uniqKey="De Jong P" first="Pim A" last="De Jong">Pim A. De Jong</name>
<affiliation wicri:level="3">
<nlm:aff id="aff29">Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name>
<affiliation wicri:level="3">
<nlm:aff id="aff27">Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff30">Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Spiering, Wilko" sort="Spiering, Wilko" uniqKey="Spiering W" first="Wilko" last="Spiering">Wilko Spiering</name>
<affiliation wicri:level="3">
<nlm:aff id="aff31">Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Der Zee, Anke H Maitland Van" sort="Der Zee, Anke H Maitland Van" uniqKey="Der Zee A" first="Anke H Maitland-Van" last="Der Zee">Anke H Maitland-Van Der Zee</name>
<affiliation wicri:level="4">
<nlm:aff id="aff16">Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
<settlement type="city">Utrecht</settlement>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author>
<name sortKey="Klungel, Olaf H" sort="Klungel, Olaf H" uniqKey="Klungel O" first="Olaf H" last="Klungel">Olaf H. Klungel</name>
<affiliation wicri:level="4">
<nlm:aff id="aff16">Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
<settlement type="city">Utrecht</settlement>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author>
<name sortKey="De Boer, Anthonius" sort="De Boer, Anthonius" uniqKey="De Boer A" first="Anthonius" last="De Boer">Anthonius De Boer</name>
<affiliation wicri:level="4">
<nlm:aff id="aff16">Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
<settlement type="city">Utrecht</settlement>
</placeName>
<orgName type="university">Université d'Utrecht</orgName>
</affiliation>
</author>
<author>
<name sortKey="Doevendans, Pieter A" sort="Doevendans, Pieter A" uniqKey="Doevendans P" first="Pieter A" last="Doevendans">Pieter A. Doevendans</name>
<affiliation wicri:level="3">
<nlm:aff id="aff32">Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Eaton, Charles B" sort="Eaton, Charles B" uniqKey="Eaton C" first="Charles B" last="Eaton">Charles B. Eaton</name>
<affiliation wicri:level="2">
<nlm:aff id="aff49">Memorial Hospital of Rhode Island, RI, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memorial Hospital of Rhode Island, RI</wicri:regionArea>
<placeName>
<region type="state">Rhode Island</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Robinson, Jennifer G" sort="Robinson, Jennifer G" uniqKey="Robinson J" first="Jennifer G" last="Robinson">Jennifer G. Robinson</name>
<affiliation wicri:level="4">
<nlm:aff id="aff50">University of Iowa, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa, IA</wicri:regionArea>
<placeName>
<region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author>
<name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name>
<affiliation wicri:level="2">
<nlm:aff id="aff51">Translational Genomics Research Institute, Phoenix, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea>
<placeName>
<region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kjekshus, John" sort="Kjekshus, John" uniqKey="Kjekshus J" first="John" last="Kjekshus">John Kjekshus</name>
<affiliation wicri:level="3">
<nlm:aff id="aff52">Department of Cardiology, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Cardiology, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo</wicri:regionArea>
<placeName>
<settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R" last="Downs">John R. Downs</name>
<affiliation wicri:level="2">
<nlm:aff id="aff54">Department of Medicine, University of Texas Health Science Centre, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of Texas Health Science Centre, San Antonio, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="aff55">VERDICT, South Texas Veterans Health Care System, San Antonio, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>VERDICT, South Texas Veterans Health Care System, San Antonio, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gotto, Antonio M" sort="Gotto, Antonio M" uniqKey="Gotto A" first="Antonio M" last="Gotto">Antonio M. Gotto</name>
<affiliation wicri:level="2">
<nlm:aff id="aff56">Weill Cornell Medical College, New York, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Weill Cornell Medical College, New York, NY</wicri:regionArea>
<placeName>
<region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Keech, Anthony C" sort="Keech, Anthony C" uniqKey="Keech A" first="Anthony C" last="Keech">Anthony C. Keech</name>
<affiliation wicri:level="4">
<nlm:aff id="aff57">NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Marchioli, Roberto" sort="Marchioli, Roberto" uniqKey="Marchioli R" first="Roberto" last="Marchioli">Roberto Marchioli</name>
<affiliation wicri:level="3">
<nlm:aff id="aff58">Hematology and Oncology Therapeutic Delivery Unit, Quintiles, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Hematology and Oncology Therapeutic Delivery Unit, Quintiles, Milan</wicri:regionArea>
<placeName>
<settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tognoni, Gianni" sort="Tognoni, Gianni" uniqKey="Tognoni G" first="Gianni" last="Tognoni">Gianni Tognoni</name>
<affiliation wicri:level="1">
<nlm:aff id="aff59">Department of Clinical Pharmacology and Epidemiology, Consorzio Mario NegriSud, Santa Maria Imbaro, Chieti, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Clinical Pharmacology and Epidemiology, Consorzio Mario NegriSud, Santa Maria Imbaro, Chieti</wicri:regionArea>
<wicri:noRegion>Chieti</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Sever, Peter S" sort="Sever, Peter S" uniqKey="Sever P" first="Peter S" last="Sever">Peter S. Sever</name>
<affiliation wicri:level="3">
<nlm:aff id="aff24">International Centre for Circulatory Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Centre for Circulatory Health, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Poulter, Neil R" sort="Poulter, Neil R" uniqKey="Poulter N" first="Neil R" last="Poulter">Neil R. Poulter</name>
<affiliation wicri:level="3">
<nlm:aff id="aff24">International Centre for Circulatory Health, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Centre for Circulatory Health, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D" last="Waters">David D. Waters</name>
<affiliation wicri:level="2">
<nlm:aff id="aff60">Department of Medicine, University of California, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, University of California, San Francisco, CA</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R" last="Pedersen">Terje R. Pedersen</name>
<affiliation wicri:level="3">
<nlm:aff id="aff53">Centre for Preventative Medicine, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Centre for Preventative Medicine, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo</wicri:regionArea>
<placeName>
<settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name>
<affiliation wicri:level="3">
<nlm:aff id="aff61">Denis Diderot University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Denis Diderot University, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nakamura, Haruo" sort="Nakamura, Haruo" uniqKey="Nakamura H" first="Haruo" last="Nakamura">Haruo Nakamura</name>
<affiliation wicri:level="3">
<nlm:aff id="aff62">Mitsukoshi Health and Welfare Foundation, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Mitsukoshi Health and Welfare Foundation, Tokyo</wicri:regionArea>
<placeName>
<settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mcmurray, John J V" sort="Mcmurray, John J V" uniqKey="Mcmurray J" first="John J V" last="Mcmurray">John J V. Mcmurray</name>
<affiliation wicri:level="4">
<nlm:aff id="aff8">BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lewsey, James D" sort="Lewsey, James D" uniqKey="Lewsey J" first="James D" last="Lewsey">James D. Lewsey</name>
<affiliation wicri:level="4">
<nlm:aff id="aff11">Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Health and Wellbeing, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name>
<affiliation wicri:level="2">
<nlm:aff id="aff63">Division of Preventive Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="2">
<nlm:aff id="aff63">Division of Preventive Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P" last="Maggioni">Aldo P. Maggioni</name>
<affiliation wicri:level="1">
<nlm:aff id="aff66">ANMCO Research Center, Florence, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>ANMCO Research Center, Florence</wicri:regionArea>
<wicri:noRegion>Florence</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Tavazzi, Luigi" sort="Tavazzi, Luigi" uniqKey="Tavazzi L" first="Luigi" last="Tavazzi">Luigi Tavazzi</name>
<affiliation wicri:level="1">
<nlm:aff id="aff67">Maria Cecilia Hospital, GVM Care and Research, E.S. Health Science Foundation, Cotignola (RA), Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Maria Cecilia Hospital, GVM Care and Research, E.S. Health Science Foundation, Cotignola (RA)</wicri:regionArea>
<wicri:noRegion>Cotignola (RA)</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ray, Kausik K" sort="Ray, Kausik K" uniqKey="Ray K" first="Kausik K" last="Ray">Kausik K. Ray</name>
<affiliation wicri:level="3">
<nlm:aff id="aff68">Cardiac and Cell Sciences Research Institute, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiac and Cell Sciences Research Institute, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Seshasai, Sreenivasa Rao Kondapally" sort="Seshasai, Sreenivasa Rao Kondapally" uniqKey="Seshasai S" first="Sreenivasa Rao Kondapally" last="Seshasai">Sreenivasa Rao Kondapally Seshasai</name>
<affiliation wicri:level="3">
<nlm:aff id="aff68">Cardiac and Cell Sciences Research Institute, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cardiac and Cell Sciences Research Institute, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name>
<affiliation wicri:level="2">
<nlm:aff id="aff63">Division of Preventive Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name>
<affiliation wicri:level="4">
<nlm:aff id="aff22">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Whincup, Peter H" sort="Whincup, Peter H" uniqKey="Whincup P" first="Peter H" last="Whincup">Peter H. Whincup</name>
<affiliation wicri:level="4">
<nlm:aff id="aff69">St George's University of London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>St George's University of London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Morris, Richard W" sort="Morris, Richard W" uniqKey="Morris R" first="Richard W" last="Morris">Richard W. Morris</name>
<affiliation wicri:level="4">
<nlm:aff id="aff5">UCL Department of Primary Care and Population Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Department of Primary Care and Population Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Integrative Epidemiology Unit, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff71">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Integrative Epidemiology Unit, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff71">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name>
<affiliation wicri:level="1">
<nlm:aff id="aff71">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schreiner, Pamela J" sort="Schreiner, Pamela J" uniqKey="Schreiner P" first="Pamela J" last="Schreiner">Pamela J. Schreiner</name>
<affiliation wicri:level="2">
<nlm:aff id="aff72">School of Public Health, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Public Health, Minneapolis, MN</wicri:regionArea>
<placeName>
<region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2">
<nlm:aff id="aff74">Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name>
<affiliation wicri:level="4">
<nlm:aff id="aff75">Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
<placeName>
<region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author>
<name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name>
<affiliation wicri:level="2">
<nlm:aff id="aff77">Departments of Medicine and Pathology, University of Vermont, Colchester, VT, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Medicine and Pathology, University of Vermont, Colchester, VT</wicri:regionArea>
<placeName>
<region type="state">Vermont</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J" last="Wareham">Nick J. Wareham</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Verschuren, W M Monique" sort="Verschuren, W M Monique" uniqKey="Verschuren W" first="W M Monique" last="Verschuren">W M Monique Verschuren</name>
<affiliation wicri:level="1">
<nlm:aff id="aff26">National Institute for Public Health and the Environment, Bilthoven, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name>
<affiliation wicri:level="2">
<nlm:aff id="aff65">Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women's Hospital, Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Patel, Sanjay R" sort="Patel, Sanjay R" uniqKey="Patel S" first="Sanjay R" last="Patel">Sanjay R. Patel</name>
<affiliation wicri:level="2">
<nlm:aff id="aff64">Division of Sleep Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Sleep Medicine, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Whittaker, John C" sort="Whittaker, John C" uniqKey="Whittaker J" first="John C" last="Whittaker">John C. Whittaker</name>
<affiliation wicri:level="1">
<nlm:aff id="aff78">GlaxoSmithKline, Stevenage, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>GlaxoSmithKline, Stevenage</wicri:regionArea>
<wicri:noRegion>Stevenage</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<affiliation wicri:level="3">
<nlm:aff id="aff42">Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Delaney, Joseph A" sort="Delaney, Joseph A" uniqKey="Delaney J" first="Joseph A" last="Delaney">Joseph A. Delaney</name>
<affiliation wicri:level="4">
<nlm:aff id="aff76">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
<placeName>
<region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author>
<name sortKey="Dale, Caroline" sort="Dale, Caroline" uniqKey="Dale C" first="Caroline" last="Dale">Caroline Dale</name>
<affiliation wicri:level="3">
<nlm:aff id="aff19">Department of Non-Communicable Disease Epidemiology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gaunt, Tom R" sort="Gaunt, Tom R" uniqKey="Gaunt T" first="Tom R" last="Gaunt">Tom R. Gaunt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Integrative Epidemiology Unit, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name>
<affiliation wicri:level="4">
<nlm:aff id="aff7">MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name>
<affiliation wicri:level="4">
<nlm:aff id="aff7">MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Hardy, Rebecca" sort="Hardy, Rebecca" uniqKey="Hardy R" first="Rebecca" last="Hardy">Rebecca Hardy</name>
<affiliation wicri:level="4">
<nlm:aff id="aff7">MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRCUnit for Lifelong Health and Ageing, Institute of Epidemiology and Health Care, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<affiliation wicri:level="2">
<nlm:aff id="aff79">Cardiology Division, Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiology Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="aff80">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Castillo, Berta A" sort="Castillo, Berta A" uniqKey="Castillo B" first="Berta A" last="Castillo">Berta A. Castillo</name>
<affiliation wicri:level="2">
<nlm:aff id="aff18">Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name>
<affiliation wicri:level="4">
<nlm:aff id="aff17">University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University of Groningen, University Medical Centre Groningen, Department of Cardiology, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
<settlement type="city">Groningue (ville)</settlement>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author>
<name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J" last="Brunner">Eric J. Brunner</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Tybjaerg Hansen, Anne" sort="Tybjaerg Hansen, Anne" uniqKey="Tybjaerg Hansen A" first="Anne" last="Tybjaerg-Hansen">Anne Tybjaerg-Hansen</name>
<affiliation wicri:level="3">
<nlm:aff id="aff14">Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen</wicri:regionArea>
<placeName>
<settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Marmot, Michael G" sort="Marmot, Michael G" uniqKey="Marmot M" first="Michael G" last="Marmot">Michael G. Marmot</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Krauss, Ronald M" sort="Krauss, Ronald M" uniqKey="Krauss R" first="Ronald M" last="Krauss">Ronald M. Krauss</name>
<affiliation wicri:level="2">
<nlm:aff id="aff81">Children's Hospital Oakland Research Institute, Oakland, CA USA</nlm:aff>
<country>États-Unis</country>
<placeName>
<region type="state">Californie</region>
</placeName>
<wicri:cityArea>Children's Hospital Oakland Research Institute, Oakland</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Tsai, Michael" sort="Tsai, Michael" uniqKey="Tsai M" first="Michael" last="Tsai">Michael Tsai</name>
<affiliation wicri:level="2">
<nlm:aff id="aff73">University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName>
<region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name>
<affiliation wicri:level="2">
<nlm:aff id="aff82">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD</wicri:regionArea>
<placeName>
<region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hoogeveen, Ronald C" sort="Hoogeveen, Ronald C" uniqKey="Hoogeveen R" first="Ronald C" last="Hoogeveen">Ronald C. Hoogeveen</name>
<affiliation wicri:level="2">
<nlm:aff id="aff83">Baylor College of Medicine, Department of Medicine, Division of Atherosclerosis and Vascular Medicine, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Baylor College of Medicine, Department of Medicine, Division of Atherosclerosis and Vascular Medicine, Houston, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name>
<affiliation wicri:level="4">
<nlm:aff id="aff75">Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit of the Department of Medicine, Department of Epidemiology, and Department of Health Services, University of Washington, Seattle, WA</wicri:regionArea>
<placeName>
<region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author>
<name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name>
<affiliation wicri:level="2">
<nlm:aff id="aff84">Department of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name>
<affiliation wicri:level="2">
<nlm:aff id="aff18">Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name>
<affiliation wicri:level="3">
<nlm:aff id="aff20">London School of Hygiene & Tropical Medicine, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London School of Hygiene & Tropical Medicine, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Talmud, Philippa J" sort="Talmud, Philippa J" uniqKey="Talmud P" first="Philippa J" last="Talmud">Philippa J. Talmud</name>
<affiliation wicri:level="4">
<nlm:aff id="aff6">Centre for Cardiovascular Genetics, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cardiovascular Genetics, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Kivim Ki, Mika" sort="Kivim Ki, Mika" uniqKey="Kivim Ki M" first="Mika" last="Kivim Ki">Mika Kivim Ki</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff70">MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Integrative Epidemiology Unit, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff71">School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge</wicri:regionArea>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff32">Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff85">Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Voevoda, Mikhail" sort="Voevoda, Mikhail" uniqKey="Voevoda M" first="Mikhail" last="Voevoda">Mikhail Voevoda</name>
<affiliation wicri:level="1">
<nlm:aff id="aff39">Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Internal and Preventive Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk</wicri:regionArea>
<wicri:noRegion>Novosibirsk</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="aff40">Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia</nlm:aff>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk</wicri:regionArea>
<wicri:noRegion>Novosibirsk</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Bobak, Martin" sort="Bobak, Martin" uniqKey="Bobak M" first="Martin" last="Bobak">Martin Bobak</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Pikhart, Hynek" sort="Pikhart, Hynek" uniqKey="Pikhart H" first="Hynek" last="Pikhart">Hynek Pikhart</name>
<affiliation wicri:level="4">
<nlm:aff id="aff3">UCL Research Department of Epidemiology and Public Health, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Research Department of Epidemiology and Public Health, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Wilson, James G" sort="Wilson, James G" uniqKey="Wilson J" first="James G" last="Wilson">James G. Wilson</name>
<affiliation wicri:level="2">
<nlm:aff id="aff86">Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName>
<region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name>
<affiliation wicri:level="2">
<nlm:aff id="aff87">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name>
<affiliation wicri:level="2">
<nlm:aff id="aff18">Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name>
<affiliation wicri:level="4">
<nlm:aff id="aff1">UCL Institute of Cardiovascular Science and Farr Institute, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Institute of Cardiovascular Science and Farr Institute, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
<settlement type="city">Londres</settlement>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author>
<name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation wicri:level="4">
<nlm:aff id="aff8">BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Lancet</title>
<idno type="ISSN">0140-6736</idno>
<idno type="eISSN">1474-547X</idno>
<imprint>
<date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Aged</term>
<term>Body Mass Index</term>
<term>Body Weight (genetics)</term>
<term>Cholesterol, HDL (metabolism)</term>
<term>Cholesterol, LDL (metabolism)</term>
<term>Diabetes Mellitus, Type 2 (genetics)</term>
<term>Female</term>
<term>Genetic Testing</term>
<term>Humans</term>
<term>Hydroxymethylglutaryl CoA Reductases (genetics)</term>
<term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adulte d'âge moyen</term>
<term>Cholestérol HDL (métabolisme)</term>
<term>Cholestérol LDL (métabolisme)</term>
<term>Diabète de type 2 (génétique)</term>
<term>Dépistage génétique</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hydroxymethylglutaryl-CoA reductases (génétique)</term>
<term>Indice de masse corporelle</term>
<term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (effets indésirables)</term>
<term>Mâle</term>
<term>Poids du corps (génétique)</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Sujet âgé</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en">
<term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Hydroxymethylglutaryl CoA Reductases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Cholesterol, HDL</term>
<term>Cholesterol, LDL</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr">
<term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Body Weight</term>
<term>Diabetes Mellitus, Type 2</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr">
<term>Diabète de type 2</term>
<term>Hydroxymethylglutaryl-CoA reductases</term>
<term>Poids du corps</term>
<term>Polymorphisme de nucléotide simple</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>Cholestérol HDL</term>
<term>Cholestérol LDL</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Body Mass Index</term>
<term>Female</term>
<term>Genetic Testing</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Randomized Controlled Trials as Topic</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Adulte d'âge moyen</term>
<term>Dépistage génétique</term>
<term>Essais contrôlés randomisés comme sujet</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Mâle</term>
<term>Sujet âgé</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<title>Summary</title>
<sec>
<title>Background</title>
<p>Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target.</p>
</sec>
<sec>
<title>Methods</title>
<p>We used single nucleotide polymorphisms in the
<italic>HMGCR</italic>
gene, rs17238484 (for the main analysis) and rs12916 (for a subsidiary analysis) as proxies for HMGCR inhibition by statins. We examined associations of these variants with plasma lipid, glucose, and insulin concentrations; bodyweight; waist circumference; and prevalent and incident type 2 diabetes. Study-specific effect estimates per copy of each LDL-lowering allele were pooled by meta-analysis. These findings were compared with a meta-analysis of new-onset type 2 diabetes and bodyweight change data from randomised trials of statin drugs. The effects of statins in each randomised trial were assessed using meta-analysis.</p>
</sec>
<sec>
<title>Findings</title>
<p>Data were available for up to 223 463 individuals from 43 genetic studies. Each additional rs17238484-G allele was associated with a mean 0·06 mmol/L (95% CI 0·05–0·07) lower LDL cholesterol and higher body weight (0·30 kg, 0·18–0·43), waist circumference (0·32 cm, 0·16–0·47), plasma insulin concentration (1·62%, 0·53–2·72), and plasma glucose concentration (0·23%, 0·02–0·44). The rs12916 SNP had similar effects on LDL cholesterol, bodyweight, and waist circumference. The rs17238484-G allele seemed to be associated with higher risk of type 2 diabetes (odds ratio [OR] per allele 1·02, 95% CI 1·00–1·05); the rs12916-T allele association was consistent (1·06, 1·03–1·09). In 129 170 individuals in randomised trials, statins lowered LDL cholesterol by 0·92 mmol/L (95% CI 0·18–1·67) at 1-year of follow-up, increased bodyweight by 0·24 kg (95% CI 0·10–0·38 in all trials; 0·33 kg, 95% CI 0·24–0·42 in placebo or standard care controlled trials and −0·15 kg, 95% CI −0·39 to 0·08 in intensive-dose
<italic>vs</italic>
moderate-dose trials) at a mean of 4·2 years (range 1·9–6·7) of follow-up, and increased the odds of new-onset type 2 diabetes (OR 1·12, 95% CI 1·06–1·18 in all trials; 1·11, 95% CI 1·03–1·20 in placebo or standard care controlled trials and 1·12, 95% CI 1·04–1·22 in intensive-dose
<italic>vs</italic>
moderate dose trials).</p>
</sec>
<sec>
<title>Interpretation</title>
<p>The increased risk of type 2 diabetes noted with statins is at least partially explained by HMGCR inhibition.</p>
</sec>
<sec>
<title>Funding</title>
<p>The funding sources are cited at the end of the paper.</p>
</sec>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct>
<analytic>
<author>
<name sortKey="Baigent, C" uniqKey="Baigent C">C Baigent</name>
</author>
<author>
<name sortKey="Blackwell, L" uniqKey="Blackwell L">L Blackwell</name>
</author>
<author>
<name sortKey="Emberson, J" uniqKey="Emberson J">J Emberson</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="O Regan, C" uniqKey="O Regan C">C O'Regan</name>
</author>
<author>
<name sortKey="Wu, P" uniqKey="Wu P">P Wu</name>
</author>
<author>
<name sortKey="Arora, P" uniqKey="Arora P">P Arora</name>
</author>
<author>
<name sortKey="Perri, D" uniqKey="Perri D">D Perri</name>
</author>
<author>
<name sortKey="Mills, Ej" uniqKey="Mills E">EJ Mills</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kearney, Pm" uniqKey="Kearney P">PM Kearney</name>
</author>
<author>
<name sortKey="Blackwell, L" uniqKey="Blackwell L">L Blackwell</name>
</author>
<author>
<name sortKey="Collins, R" uniqKey="Collins R">R Collins</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Pencina, Mj" uniqKey="Pencina M">MJ Pencina</name>
</author>
<author>
<name sortKey="Navar Boggan, Am" uniqKey="Navar Boggan A">AM Navar-Boggan</name>
</author>
<author>
<name sortKey="D Agostino, Rb" uniqKey="D Agostino R">RB D'Agostino</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sattar, N" uniqKey="Sattar N">N Sattar</name>
</author>
<author>
<name sortKey="Preiss, D" uniqKey="Preiss D">D Preiss</name>
</author>
<author>
<name sortKey="Murray, Hm" uniqKey="Murray H">HM Murray</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Preiss, D" uniqKey="Preiss D">D Preiss</name>
</author>
<author>
<name sortKey="Seshasai, Srk" uniqKey="Seshasai S">SRK Seshasai</name>
</author>
<author>
<name sortKey="Welsh, P" uniqKey="Welsh P">P Welsh</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Carter, Aa" uniqKey="Carter A">AA Carter</name>
</author>
<author>
<name sortKey="Gomes, T" uniqKey="Gomes T">T Gomes</name>
</author>
<author>
<name sortKey="Camacho, X" uniqKey="Camacho X">X Camacho</name>
</author>
<author>
<name sortKey="Juurlink, Dn" uniqKey="Juurlink D">DN Juurlink</name>
</author>
<author>
<name sortKey="Shah, Br" uniqKey="Shah B">BR Shah</name>
</author>
<author>
<name sortKey="Mamdani, Mm" uniqKey="Mamdani M">MM Mamdani</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Navarese, Ep" uniqKey="Navarese E">EP Navarese</name>
</author>
<author>
<name sortKey="Buffon, A" uniqKey="Buffon A">A Buffon</name>
</author>
<author>
<name sortKey="Andreotti, F" uniqKey="Andreotti F">F Andreotti</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Danaei, G" uniqKey="Danaei G">G Danaei</name>
</author>
<author>
<name sortKey="Garcia Rodriguez, La" uniqKey="Garcia Rodriguez L">LA García Rodríguez</name>
</author>
<author>
<name sortKey="Fernandez Cantero, O" uniqKey="Fernandez Cantero O">O Fernandez Cantero</name>
</author>
<author>
<name sortKey="Hernan, Ma" uniqKey="Hernan M">MA Hernán</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Davignon, J" uniqKey="Davignon J">J Davignon</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Axsom, K" uniqKey="Axsom K">K Axsom</name>
</author>
<author>
<name sortKey="Berger, Js" uniqKey="Berger J">JS Berger</name>
</author>
<author>
<name sortKey="Schwartzbard, Az" uniqKey="Schwartzbard A">AZ Schwartzbard</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Liao, Jk" uniqKey="Liao J">JK Liao</name>
</author>
<author>
<name sortKey="Laufs, U" uniqKey="Laufs U">U Laufs</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Smith, Gd" uniqKey="Smith G">GD Smith</name>
</author>
<author>
<name sortKey="Ebrahim, S" uniqKey="Ebrahim S">S Ebrahim</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Hingorani, A" uniqKey="Hingorani A">A Hingorani</name>
</author>
<author>
<name sortKey="Humphries, S" uniqKey="Humphries S">S Humphries</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Marmot, Mg" uniqKey="Marmot M">MG Marmot</name>
</author>
<author>
<name sortKey="Smith, Gd" uniqKey="Smith G">GD Smith</name>
</author>
<author>
<name sortKey="Stansfeld, S" uniqKey="Stansfeld S">S Stansfeld</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Keating, Bj" uniqKey="Keating B">BJ Keating</name>
</author>
<author>
<name sortKey="Tischfield, S" uniqKey="Tischfield S">S Tischfield</name>
</author>
<author>
<name sortKey="Murray, Ss" uniqKey="Murray S">SS Murray</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kathiresan, S" uniqKey="Kathiresan S">S Kathiresan</name>
</author>
<author>
<name sortKey="Melander, O" uniqKey="Melander O">O Melander</name>
</author>
<author>
<name sortKey="Guiducci, C" uniqKey="Guiducci C">C Guiducci</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Willer, Cj" uniqKey="Willer C">CJ Willer</name>
</author>
<author>
<name sortKey="Schmidt, Em" uniqKey="Schmidt E">EM Schmidt</name>
</author>
<author>
<name sortKey="Sengupta, S" uniqKey="Sengupta S">S Sengupta</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sheehan, Na" uniqKey="Sheehan N">NA Sheehan</name>
</author>
<author>
<name sortKey="Didelez, V" uniqKey="Didelez V">V Didelez</name>
</author>
<author>
<name sortKey="Burton, Pr" uniqKey="Burton P">PR Burton</name>
</author>
<author>
<name sortKey="Tobin, Md" uniqKey="Tobin M">MD Tobin</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="De Lemos, Ja" uniqKey="De Lemos J">JA De Lemos</name>
</author>
<author>
<name sortKey="Blazing, Ma" uniqKey="Blazing M">MA Blazing</name>
</author>
<author>
<name sortKey="Wiviott, Sd" uniqKey="Wiviott S">SD Wiviott</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kjekshus, J" uniqKey="Kjekshus J">J Kjekshus</name>
</author>
<author>
<name sortKey="Apetrei, E" uniqKey="Apetrei E">E Apetrei</name>
</author>
<author>
<name sortKey="Barrios, V" uniqKey="Barrios V">V Barrios</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Amarenco, P" uniqKey="Amarenco P">P Amarenco</name>
</author>
<author>
<name sortKey="Bogousslavsky, J" uniqKey="Bogousslavsky J">J Bogousslavsky</name>
</author>
<author>
<name sortKey="Callahan, A" uniqKey="Callahan A">A Callahan</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Higgins, Jpt" uniqKey="Higgins J">JPT Higgins</name>
</author>
<author>
<name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name>
</author>
<author>
<name sortKey="Deeks, Jj" uniqKey="Deeks J">JJ Deeks</name>
</author>
<author>
<name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Speliotes, Ek" uniqKey="Speliotes E">EK Speliotes</name>
</author>
<author>
<name sortKey="Willer, Cj" uniqKey="Willer C">CJ Willer</name>
</author>
<author>
<name sortKey="Berndt, Si" uniqKey="Berndt S">SI Berndt</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Scott, Ra" uniqKey="Scott R">RA Scott</name>
</author>
<author>
<name sortKey="Lagou, V" uniqKey="Lagou V">V Lagou</name>
</author>
<author>
<name sortKey="Welch, Rp" uniqKey="Welch R">RP Welch</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Morris, Ap" uniqKey="Morris A">AP Morris</name>
</author>
<author>
<name sortKey="Voight, Bf" uniqKey="Voight B">BF Voight</name>
</author>
<author>
<name sortKey="Teslovich, Tm" uniqKey="Teslovich T">TM Teslovich</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Voight, Bf" uniqKey="Voight B">BF Voight</name>
</author>
<author>
<name sortKey="Kang, Hm" uniqKey="Kang H">HM Kang</name>
</author>
<author>
<name sortKey="Ding, J" uniqKey="Ding J">J Ding</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Holmes, Mv" uniqKey="Holmes M">MV Holmes</name>
</author>
<author>
<name sortKey="Lange, La" uniqKey="Lange L">LA Lange</name>
</author>
<author>
<name sortKey="Palmer, T" uniqKey="Palmer T">T Palmer</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Koh, Kk" uniqKey="Koh K">KK Koh</name>
</author>
<author>
<name sortKey="Quon, Mj" uniqKey="Quon M">MJ Quon</name>
</author>
<author>
<name sortKey="Han, Sh" uniqKey="Han S">SH Han</name>
</author>
<author>
<name sortKey="Lee, Y" uniqKey="Lee Y">Y Lee</name>
</author>
<author>
<name sortKey="Kim, Sj" uniqKey="Kim S">SJ Kim</name>
</author>
<author>
<name sortKey="Shin, Ek" uniqKey="Shin E">EK Shin</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Baker, Wl" uniqKey="Baker W">WL Baker</name>
</author>
<author>
<name sortKey="Talati, R" uniqKey="Talati R">R Talati</name>
</author>
<author>
<name sortKey="White, Cm" uniqKey="White C">CM White</name>
</author>
<author>
<name sortKey="Coleman, Ci" uniqKey="Coleman C">CI Coleman</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ridker, Pm" uniqKey="Ridker P">PM Ridker</name>
</author>
<author>
<name sortKey="Danielson, E" uniqKey="Danielson E">E Danielson</name>
</author>
<author>
<name sortKey="Fonseca, Fah" uniqKey="Fonseca F">FAH Fonseca</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sabatine, Ms" uniqKey="Sabatine M">MS Sabatine</name>
</author>
<author>
<name sortKey="Wiviott, Sd" uniqKey="Wiviott S">SD Wiviott</name>
</author>
<author>
<name sortKey="Morrow, Da" uniqKey="Morrow D">DA Morrow</name>
</author>
<author>
<name sortKey="Mccabe, C" uniqKey="Mccabe C">C McCabe</name>
</author>
<author>
<name sortKey="Cannon, Cp" uniqKey="Cannon C">CP Cannon</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Holman, Rr" uniqKey="Holman R">RR Holman</name>
</author>
<author>
<name sortKey="Paul, S" uniqKey="Paul S">S Paul</name>
</author>
<author>
<name sortKey="Farmer, A" uniqKey="Farmer A">A Farmer</name>
</author>
<author>
<name sortKey="Tucker, L" uniqKey="Tucker L">L Tucker</name>
</author>
<author>
<name sortKey="Stratton, Im" uniqKey="Stratton I">IM Stratton</name>
</author>
<author>
<name sortKey="Neil, Haw" uniqKey="Neil H">HAW Neil</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Sattar, N" uniqKey="Sattar N">N Sattar</name>
</author>
<author>
<name sortKey="Taskinen, M R" uniqKey="Taskinen M">M-R Taskinen</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ridker, Pm" uniqKey="Ridker P">PM Ridker</name>
</author>
<author>
<name sortKey="Pradhan, A" uniqKey="Pradhan A">A Pradhan</name>
</author>
<author>
<name sortKey="Macfadyen, Jg" uniqKey="Macfadyen J">JG MacFadyen</name>
</author>
<author>
<name sortKey="Libby, P" uniqKey="Libby P">P Libby</name>
</author>
<author>
<name sortKey="Glynn, Rj" uniqKey="Glynn R">RJ Glynn</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>Danemark</li>
<li>France</li>
<li>Italie</li>
<li>Japon</li>
<li>Lituanie</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>Russie</li>
<li>République tchèque</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region>
<li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Arizona</li>
<li>Bohême centrale</li>
<li>Californie</li>
<li>Caroline du Nord</li>
<li>Grand Londres</li>
<li>Groningue (province)</li>
<li>Hambourg</li>
<li>Hollande-Méridionale</li>
<li>Hovedstaden</li>
<li>Iowa</li>
<li>Lombardie</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>Nouvelle-Galles du Sud</li>
<li>Pennsylvanie</li>
<li>Rhode Island</li>
<li>Région de Kantō</li>
<li>Svealand</li>
<li>Texas</li>
<li>Utrecht (province)</li>
<li>Vermont</li>
<li>Washington (État)</li>
<li>Écosse</li>
<li>État de New York</li>
<li>État du Mississippi</li>
<li>Île-de-France</li>
<li>Østlandet</li>
</region>
<settlement>
<li>Cambridge</li>
<li>Copenhague</li>
<li>Glasgow</li>
<li>Groningue</li>
<li>Groningue (ville)</li>
<li>Hambourg</li>
<li>Iowa City</li>
<li>Leyde</li>
<li>Londres</li>
<li>Milan</li>
<li>Oslo</li>
<li>Paris</li>
<li>Prague</li>
<li>Seattle</li>
<li>Stockholm</li>
<li>Sydney</li>
<li>Tokyo</li>
<li>Utrecht</li>
<li>Édimbourg</li>
</settlement>
<orgName>
<li>University College de Londres</li>
<li>Université d'Utrecht</li>
<li>Université d'Édimbourg</li>
<li>Université de Cambridge</li>
<li>Université de Glasgow</li>
<li>Université de Groningue</li>
<li>Université de Londres</li>
<li>Université de Sydney</li>
<li>Université de Washington</li>
<li>Université de l'Iowa</li>
</orgName>
</list>
<tree>
<country name="Royaume-Uni">
<region name="Angleterre">
<name sortKey="Swerdlow, Daniel I" sort="Swerdlow, Daniel I" uniqKey="Swerdlow D" first="Daniel I" last="Swerdlow">Daniel I. Swerdlow</name>
</region>
<name sortKey="Amuzu, Antoinette" sort="Amuzu, Antoinette" uniqKey="Amuzu A" first="Antoinette" last="Amuzu">Antoinette Amuzu</name>
<name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name>
<name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name>
<name sortKey="Bobak, Martin" sort="Bobak, Martin" uniqKey="Bobak M" first="Martin" last="Bobak">Martin Bobak</name>
<name sortKey="Brunner, Eric J" sort="Brunner, Eric J" uniqKey="Brunner E" first="Eric J" last="Brunner">Eric J. Brunner</name>
<name sortKey="Chung, Christina" sort="Chung, Christina" uniqKey="Chung C" first="Christina" last="Chung">Christina Chung</name>
<name sortKey="Cooper, Jackie A" sort="Cooper, Jackie A" uniqKey="Cooper J" first="Jackie A" last="Cooper">Jackie A. Cooper</name>
<name sortKey="Dale, Caroline" sort="Dale, Caroline" uniqKey="Dale C" first="Caroline" last="Dale">Caroline Dale</name>
<name sortKey="Drenos, Fotios" sort="Drenos, Fotios" uniqKey="Drenos F" first="Fotios" last="Drenos">Fotios Drenos</name>
<name sortKey="Dudbridge, Frank" sort="Dudbridge, Frank" uniqKey="Dudbridge F" first="Frank" last="Dudbridge">Frank Dudbridge</name>
<name sortKey="Engmann, Jorgen E L" sort="Engmann, Jorgen E L" uniqKey="Engmann J" first="Jorgen E L" last="Engmann">Jorgen E L. Engmann</name>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<name sortKey="Forouhi, Nita G" sort="Forouhi, Nita G" uniqKey="Forouhi N" first="Nita G" last="Forouhi">Nita G. Forouhi</name>
<name sortKey="Gallacher, John" sort="Gallacher, John" uniqKey="Gallacher J" first="John" last="Gallacher">John Gallacher</name>
<name sortKey="Gaunt, Tom R" sort="Gaunt, Tom R" uniqKey="Gaunt T" first="Tom R" last="Gaunt">Tom R. Gaunt</name>
<name sortKey="Giambartolomei, Claudia" sort="Giambartolomei, Claudia" uniqKey="Giambartolomei C" first="Claudia" last="Giambartolomei">Claudia Giambartolomei</name>
<name sortKey="Hardy, Rebecca" sort="Hardy, Rebecca" uniqKey="Hardy R" first="Rebecca" last="Hardy">Rebecca Hardy</name>
<name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name>
<name sortKey="Holmes, Michael V" sort="Holmes, Michael V" uniqKey="Holmes M" first="Michael V" last="Holmes">Michael V. Holmes</name>
<name sortKey="Howard, Philip" sort="Howard, Philip" uniqKey="Howard P" first="Philip" last="Howard">Philip Howard</name>
<name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name>
<name sortKey="Johnson, Paul C D" sort="Johnson, Paul C D" uniqKey="Johnson P" first="Paul C D" last="Johnson">Paul C D. Johnson</name>
<name sortKey="Kivim Ki, Mika" sort="Kivim Ki, Mika" uniqKey="Kivim Ki M" first="Mika" last="Kivim Ki">Mika Kivim Ki</name>
<name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B" last="Kuchenbaecker">Karoline B. Kuchenbaecker</name>
<name sortKey="Kuh, Diana" sort="Kuh, Diana" uniqKey="Kuh D" first="Diana" last="Kuh">Diana Kuh</name>
<name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name>
<name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name>
<name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name>
<name sortKey="Lawlor, Debbie A" sort="Lawlor, Debbie A" uniqKey="Lawlor D" first="Debbie A" last="Lawlor">Debbie A. Lawlor</name>
<name sortKey="Lewsey, James D" sort="Lewsey, James D" uniqKey="Lewsey J" first="James D" last="Lewsey">James D. Lewsey</name>
<name sortKey="Li, Kawah" sort="Li, Kawah" uniqKey="Li K" first="Kawah" last="Li">Kawah Li</name>
<name sortKey="Lowe, Gordon" sort="Lowe, Gordon" uniqKey="Lowe G" first="Gordon" last="Lowe">Gordon Lowe</name>
<name sortKey="Marmot, Michael G" sort="Marmot, Michael G" uniqKey="Marmot M" first="Michael G" last="Marmot">Michael G. Marmot</name>
<name sortKey="Mcmurray, John J V" sort="Mcmurray, John J V" uniqKey="Mcmurray J" first="John J V" last="Mcmurray">John J V. Mcmurray</name>
<name sortKey="Morris, Richard W" sort="Morris, Richard W" uniqKey="Morris R" first="Richard W" last="Morris">Richard W. Morris</name>
<name sortKey="Palmen, Jutta" sort="Palmen, Jutta" uniqKey="Palmen J" first="Jutta" last="Palmen">Jutta Palmen</name>
<name sortKey="Peasey, Anne" sort="Peasey, Anne" uniqKey="Peasey A" first="Anne" last="Peasey">Anne Peasey</name>
<name sortKey="Pikhart, Hynek" sort="Pikhart, Hynek" uniqKey="Pikhart H" first="Hynek" last="Pikhart">Hynek Pikhart</name>
<name sortKey="Poulter, Neil R" sort="Poulter, Neil R" uniqKey="Poulter N" first="Neil R" last="Poulter">Neil R. Poulter</name>
<name sortKey="Preiss, David" sort="Preiss, David" uniqKey="Preiss D" first="David" last="Preiss">David Preiss</name>
<name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name>
<name sortKey="Ray, Kausik K" sort="Ray, Kausik K" uniqKey="Ray K" first="Kausik K" last="Ray">Kausik K. Ray</name>
<name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<name sortKey="Scott, Robert A" sort="Scott, Robert A" uniqKey="Scott R" first="Robert A" last="Scott">Robert A. Scott</name>
<name sortKey="Seshasai, Sreenivasa Rao Kondapally" sort="Seshasai, Sreenivasa Rao Kondapally" uniqKey="Seshasai S" first="Sreenivasa Rao Kondapally" last="Seshasai">Sreenivasa Rao Kondapally Seshasai</name>
<name sortKey="Sever, Peter S" sort="Sever, Peter S" uniqKey="Sever P" first="Peter S" last="Sever">Peter S. Sever</name>
<name sortKey="Shah, Tina" sort="Shah, Tina" uniqKey="Shah T" first="Tina" last="Shah">Tina Shah</name>
<name sortKey="Sharp, Stephen J" sort="Sharp, Stephen J" uniqKey="Sharp S" first="Stephen J" last="Sharp">Stephen J. Sharp</name>
<name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name>
<name sortKey="Smith, George Davey" sort="Smith, George Davey" uniqKey="Smith G" first="George Davey" last="Smith">George Davey Smith</name>
<name sortKey="Sofat, Reecha" sort="Sofat, Reecha" uniqKey="Sofat R" first="Reecha" last="Sofat">Reecha Sofat</name>
<name sortKey="Stewart, Marlene C W" sort="Stewart, Marlene C W" uniqKey="Stewart M" first="Marlene C W" last="Stewart">Marlene C W. Stewart</name>
<name sortKey="Talmud, Philippa J" sort="Talmud, Philippa J" uniqKey="Talmud P" first="Philippa J" last="Talmud">Philippa J. Talmud</name>
<name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name>
<name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J" last="Timpson">Nicholas J. Timpson</name>
<name sortKey="Tzoulaki, Ioanna" sort="Tzoulaki, Ioanna" uniqKey="Tzoulaki I" first="Ioanna" last="Tzoulaki">Ioanna Tzoulaki</name>
<name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J" last="Wareham">Nick J. Wareham</name>
<name sortKey="Whincup, Peter H" sort="Whincup, Peter H" uniqKey="Whincup P" first="Peter H" last="Whincup">Peter H. Whincup</name>
<name sortKey="Whittaker, John C" sort="Whittaker, John C" uniqKey="Whittaker J" first="John C" last="Whittaker">John C. Whittaker</name>
<name sortKey="Wong, Andrew" sort="Wong, Andrew" uniqKey="Wong A" first="Andrew" last="Wong">Andrew Wong</name>
</country>
<country name="États-Unis">
<region name="Pennsylvanie">
<name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B" last="Kuchenbaecker">Karoline B. Kuchenbaecker</name>
</region>
<name sortKey="Buxbaum, Sarah G" sort="Buxbaum, Sarah G" uniqKey="Buxbaum S" first="Sarah G" last="Buxbaum">Sarah G. Buxbaum</name>
<name sortKey="Castillo, Berta A" sort="Castillo, Berta A" uniqKey="Castillo B" first="Berta A" last="Castillo">Berta A. Castillo</name>
<name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name>
<name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name>
<name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name>
<name sortKey="Delaney, Joseph A" sort="Delaney, Joseph A" uniqKey="Delaney J" first="Joseph A" last="Delaney">Joseph A. Delaney</name>
<name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R" last="Downs">John R. Downs</name>
<name sortKey="Downs, John R" sort="Downs, John R" uniqKey="Downs J" first="John R" last="Downs">John R. Downs</name>
<name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name>
<name sortKey="Eaton, Charles B" sort="Eaton, Charles B" uniqKey="Eaton C" first="Charles B" last="Eaton">Charles B. Eaton</name>
<name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<name sortKey="Gotto, Antonio M" sort="Gotto, Antonio M" uniqKey="Gotto A" first="Antonio M" last="Gotto">Antonio M. Gotto</name>
<name sortKey="Guo, Yiran" sort="Guo, Yiran" uniqKey="Guo Y" first="Yiran" last="Guo">Yiran Guo</name>
<name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name>
<name sortKey="Hoogeveen, Ronald C" sort="Hoogeveen, Ronald C" uniqKey="Hoogeveen R" first="Ronald C" last="Hoogeveen">Ronald C. Hoogeveen</name>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name>
<name sortKey="Krauss, Ronald M" sort="Krauss, Ronald M" uniqKey="Krauss R" first="Ronald M" last="Krauss">Ronald M. Krauss</name>
<name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name>
<name sortKey="Li, Yun R" sort="Li, Yun R" uniqKey="Li Y" first="Yun R" last="Li">Yun R. Li</name>
<name sortKey="Manson, Joann E" sort="Manson, Joann E" uniqKey="Manson J" first="Joann E" last="Manson">Joann E. Manson</name>
<name sortKey="Patel, Sanjay R" sort="Patel, Sanjay R" uniqKey="Patel S" first="Sanjay R" last="Patel">Sanjay R. Patel</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name>
<name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name>
<name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name>
<name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<name sortKey="Robinson, Jennifer G" sort="Robinson, Jennifer G" uniqKey="Robinson J" first="Jennifer G" last="Robinson">Jennifer G. Robinson</name>
<name sortKey="Schreiner, Pamela J" sort="Schreiner, Pamela J" uniqKey="Schreiner P" first="Pamela J" last="Schreiner">Pamela J. Schreiner</name>
<name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S" last="Siscovick">David S. Siscovick</name>
<name sortKey="Tsai, Michael" sort="Tsai, Michael" uniqKey="Tsai M" first="Michael" last="Tsai">Michael Tsai</name>
<name sortKey="Waters, David D" sort="Waters, David D" uniqKey="Waters D" first="David D" last="Waters">David D. Waters</name>
<name sortKey="Wilson, James G" sort="Wilson, James G" uniqKey="Wilson J" first="James G" last="Wilson">James G. Wilson</name>
</country>
<country name="Danemark">
<region name="Hovedstaden">
<name sortKey="Stender, Stefan" sort="Stender, Stefan" uniqKey="Stender S" first="Stefan" last="Stender">Stefan Stender</name>
</region>
<name sortKey="Tybjaerg Hansen, Anne" sort="Tybjaerg Hansen, Anne" uniqKey="Tybjaerg Hansen A" first="Anne" last="Tybjaerg-Hansen">Anne Tybjaerg-Hansen</name>
</country>
<country name="Pays-Bas">
<region name="Utrecht (province)">
<name sortKey="Leusink, Maarten" sort="Leusink, Maarten" uniqKey="Leusink M" first="Maarten" last="Leusink">Maarten Leusink</name>
</region>
<name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name>
<name sortKey="Algra, Ale" sort="Algra, Ale" uniqKey="Algra A" first="Ale" last="Algra">Ale Algra</name>
<name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name>
<name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name>
<name sortKey="De Boer, Anthonius" sort="De Boer, Anthonius" uniqKey="De Boer A" first="Anthonius" last="De Boer">Anthonius De Boer</name>
<name sortKey="De Borst, Gert Jan" sort="De Borst, Gert Jan" uniqKey="De Borst G" first="Gert Jan" last="De Borst">Gert Jan De Borst</name>
<name sortKey="De Jong, Pim A" sort="De Jong, Pim A" uniqKey="De Jong P" first="Pim A" last="De Jong">Pim A. De Jong</name>
<name sortKey="Der Zee, Anke H Maitland Van" sort="Der Zee, Anke H Maitland Van" uniqKey="Der Zee A" first="Anke H Maitland-Van" last="Der Zee">Anke H Maitland-Van Der Zee</name>
<name sortKey="Doevendans, Pieter A" sort="Doevendans, Pieter A" uniqKey="Doevendans P" first="Pieter A" last="Doevendans">Pieter A. Doevendans</name>
<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name>
<name sortKey="Klungel, Olaf H" sort="Klungel, Olaf H" uniqKey="Klungel O" first="Olaf H" last="Klungel">Olaf H. Klungel</name>
<name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name>
<name sortKey="Spiering, Wilko" sort="Spiering, Wilko" uniqKey="Spiering W" first="Wilko" last="Spiering">Wilko Spiering</name>
<name sortKey="Van Der A, Daphne L" sort="Van Der A, Daphne L" uniqKey="Van Der A D" first="Daphne L" last="Van Der A">Daphne L. Van Der A</name>
<name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name>
<name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name>
<name sortKey="Verschuren, W M Monique" sort="Verschuren, W M Monique" uniqKey="Verschuren W" first="W M Monique" last="Verschuren">W M Monique Verschuren</name>
<name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name>
<name sortKey="Westendorp, Rudi G J" sort="Westendorp, Rudi G J" uniqKey="Westendorp R" first="Rudi G J" last="Westendorp">Rudi G J. Westendorp</name>
</country>
<country name="Allemagne">
<region name="Hambourg">
<name sortKey="Schnabel, Renate B" sort="Schnabel, Renate B" uniqKey="Schnabel R" first="Renate B" last="Schnabel">Renate B. Schnabel</name>
</region>
</country>
<country name="République tchèque">
<region name="Bohême centrale">
<name sortKey="Hubacek, Jaroslav A" sort="Hubacek, Jaroslav A" uniqKey="Hubacek J" first="Jaroslav A" last="Hubacek">Jaroslav A. Hubacek</name>
</region>
<name sortKey="Kubinova, Ruzena" sort="Kubinova, Ruzena" uniqKey="Kubinova R" first="Ruzena" last="Kubinova">Ruzena Kubinova</name>
</country>
<country name="Lituanie">
<noRegion>
<name sortKey="Baceviciene, Migle" sort="Baceviciene, Migle" uniqKey="Baceviciene M" first="Migle" last="Baceviciene">Migle Baceviciene</name>
</noRegion>
<name sortKey="Tamosiunas, Abdonas" sort="Tamosiunas, Abdonas" uniqKey="Tamosiunas A" first="Abdonas" last="Tamosiunas">Abdonas Tamosiunas</name>
</country>
<country name="Pologne">
<noRegion>
<name sortKey="Pajak, Andrzej" sort="Pajak, Andrzej" uniqKey="Pajak A" first="Andrzej" last="Pajak">Andrzej Pajak</name>
</noRegion>
<name sortKey="Stepaniak, Urszula" sort="Stepaniak, Urszula" uniqKey="Stepaniak U" first="Urszula" last="Stepaniak">Urszula Stepaniak</name>
<name sortKey="Topor Madry, Romanvan" sort="Topor Madry, Romanvan" uniqKey="Topor Madry R" first="Romanvan" last="Topor-Madry">Romanvan Topor-Madry</name>
</country>
<country name="Russie">
<noRegion>
<name sortKey="Malyutina, Sofia" sort="Malyutina, Sofia" uniqKey="Malyutina S" first="Sofia" last="Malyutina">Sofia Malyutina</name>
</noRegion>
<name sortKey="Voevoda, Mikhail" sort="Voevoda, Mikhail" uniqKey="Voevoda M" first="Mikhail" last="Voevoda">Mikhail Voevoda</name>
<name sortKey="Voevoda, Mikhail" sort="Voevoda, Mikhail" uniqKey="Voevoda M" first="Mikhail" last="Voevoda">Mikhail Voevoda</name>
</country>
<country name="Italie">
<region name="Lombardie">
<name sortKey="Baldassarre, Damiano" sort="Baldassarre, Damiano" uniqKey="Baldassarre D" first="Damiano" last="Baldassarre">Damiano Baldassarre</name>
</region>
<name sortKey="Baldassarre, Damiano" sort="Baldassarre, Damiano" uniqKey="Baldassarre D" first="Damiano" last="Baldassarre">Damiano Baldassarre</name>
<name sortKey="Maggioni, Aldo P" sort="Maggioni, Aldo P" uniqKey="Maggioni A" first="Aldo P" last="Maggioni">Aldo P. Maggioni</name>
<name sortKey="Marchioli, Roberto" sort="Marchioli, Roberto" uniqKey="Marchioli R" first="Roberto" last="Marchioli">Roberto Marchioli</name>
<name sortKey="Tavazzi, Luigi" sort="Tavazzi, Luigi" uniqKey="Tavazzi L" first="Luigi" last="Tavazzi">Luigi Tavazzi</name>
<name sortKey="Tognoni, Gianni" sort="Tognoni, Gianni" uniqKey="Tognoni G" first="Gianni" last="Tognoni">Gianni Tognoni</name>
<name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name>
<name sortKey="Tremoli, Elena" sort="Tremoli, Elena" uniqKey="Tremoli E" first="Elena" last="Tremoli">Elena Tremoli</name>
<name sortKey="Veglia, Fabrizio" sort="Veglia, Fabrizio" uniqKey="Veglia F" first="Fabrizio" last="Veglia">Fabrizio Veglia</name>
</country>
<country name="Suède">
<region name="Svealand">
<name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
</region>
<name sortKey="De Faire, Ulf" sort="De Faire, Ulf" uniqKey="De Faire U" first="Ulf" last="De Faire">Ulf De Faire</name>
<name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name>
</country>
<country name="Norvège">
<region name="Østlandet">
<name sortKey="Kjekshus, John" sort="Kjekshus, John" uniqKey="Kjekshus J" first="John" last="Kjekshus">John Kjekshus</name>
</region>
<name sortKey="Pedersen, Terje R" sort="Pedersen, Terje R" uniqKey="Pedersen T" first="Terje R" last="Pedersen">Terje R. Pedersen</name>
</country>
<country name="Australie">
<region name="Nouvelle-Galles du Sud">
<name sortKey="Keech, Anthony C" sort="Keech, Anthony C" uniqKey="Keech A" first="Anthony C" last="Keech">Anthony C. Keech</name>
</region>
</country>
<country name="France">
<region name="Île-de-France">
<name sortKey="Amarenco, Pierre" sort="Amarenco, Pierre" uniqKey="Amarenco P" first="Pierre" last="Amarenco">Pierre Amarenco</name>
</region>
</country>
<country name="Japon">
<region name="Région de Kantō">
<name sortKey="Nakamura, Haruo" sort="Nakamura, Haruo" uniqKey="Nakamura H" first="Haruo" last="Nakamura">Haruo Nakamura</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D19 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002D19 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4322187
   |texte=   HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:25262344" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1
Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024